Methyl hydrogen silicone fluid is highly effective as an antifoam and defoamer in chemical processing, wastewater treatment, and food production. Its low surface tension (20–21 mN/m) disrupts foam stability by entering lamellae and weakening bubble structures.

In fermentation processes, MHSF-based defoamers reduce foam volume by 90% at concentrations as low as 10 ppm. Its thermal stability (up to 250°C) makes it suitable for high-temperature applications like petroleum refining, where it prevents foam-induced inefficiencies in distillation columns. New microemulsion technologies enhance its dispersibility in aqueous systems, expanding its use in eco-friendly formulations.